The CRC 1080 "Molecular and cellular mechanisms of neural homeostasis" aims to understand how the delicate balance between excitation and inhibition of neurons is maintained during the development of an organism and under physiological and pathological conditions, how it is constantly regulated by the neural network and dynamically adjusted after disturbances to promote neural network functionality. To investigate the self-regulatory activity of the brain, the consortium has chosen a translational approach bridging basic science and clinical application. The projects will deploy different in vitro and in vivo models in order to gain a deeper understanding of patient data obtained by high resolution imaging and to develop new therapies to tackle neurodegenerative diseases. This CRC connects PIs of the Johannes Gutenberg-University of Mainz, the University Medical Center Mainz, the Institute of Molecular Biology Mainz, several institutes of the Goethe-University Frankfurt (Coordinator: Univ.-Prof. Dr. A. Acker-Palmer) and the Max Planck-Institutes for Biophysics and for Brain Research in Frankfurt.
start: January 2013
Univ.- Prof. Dr. H. Luhmann (Co-Coordinator)
Institute for Physiology
Since 2013, the CRC 1066 "Nanodimensional polymer therapeutics for tumor therapy" has been dedicated to the development of a nanoparticle-based tumor therapy against melenoma as an immunogenic Tumor model. The CRC is especially characterized through its interdisciplinary nature: chemists work on the synthetic capabilities and the relationship between the structure of the carrier materials while immunologists and biomedical engineers develop the concepts for optimal installation of the carrier materials with the purpose of developing a combination therapy that will activate the immune system against tumors.
Scientists from the Johannes Gutenberg-University Mainz and the Max-Planck-Insitute for Polymer Research are working together to develop a tumor therapy that is adapted to eliminate side effects and related illnesses, for example hidden metastases.
start: October 2013
Johannes Gutenberg-University Mainz:
Univ.- Prof. Dr. Rudold Zentel (coordinator)
Institute for Organic Chemistry
University Medical Center
Univ.-Prof. Dr. Stephan Grabbe (co-coordinator)
Dermatology Clinic and Policlinic
CRC 1193: "Neurobiology of resilience to stress-related mental dysfunction: from understanding mechanisms to promoting prevention" aims to understand neurobiological mechanisms of resilience to stress-induced mental dysfunction and to develop strategies to improve mental resilience.
start: July 2016
Univ.-Prof. Dr. B. Lutz (Coordinator)
Institute for Physiological Chemistry
Tel.: 06131 39-25912